Queen of Ambition tell story of Yoon Na Ri, a very poor woman who dreams to be a first lady and a man, Choi Kang Chan who sacrifices everything to help her. During the journey, they experience love, betrayal, unstoppable greed and conspiracy. This is based on the third installment of the 21-part Daemul comic series by famed Korean comic writer Park In Kwon, that was published in 2006.