Takeru Tenkūji, whose father is a ghost hunter who died 10 years earlier, dies at the hands of an evil monster known as a Ganma (眼魔, lit. "Eye Demon") when trying to protect his friend Akari Tsukimura from an attack. A mysterious hermit brings Takeru back to life and bestows upon him the Ghost Driver transformation belt and an Eyecons (眼魂（アイコン） Aikon, literally "Eye Souls"). The hermit tells Takeru that he has 99 days to gather the remaining 15 Eyecons in order to be brought back to life permanently, and he must fight the Ganma as Kamen Rider Ghost to obtain them. He is assisted by the Shinto priest Onari, who previously supported his father as a ghost hunter, as well Akari, Takeru's childhood friend who tries to find more scientific reasons behind their supernatural encounters. In his way are Makoto Fukami, another young man with a Ghost Driver who can transform into Kamen Rider Specter (仮面ライダースペクター Kamen Raidā Supekutā), and the Ganma led by Aran and his mysterious benefactor.