The once prosperous Planet Bio (バイオ星 Baio-sei?) is destroyed after a world war erupted over the use of a scientific discovery called "Bio Particles". The Planet Bio Peacekeeping Alliance (バイオ星平和連合 Baio-sei Heiwa Rengō?), which sought to use Bio Particles for peaceful purposes, sends the giant robot Bio Robo and an assistant robot named Peebo in order to prevent the same tragedy from happening on Earth. Bio Robo arrives on 15th century Japan, where it showers Bio Particles on five young individuals. Five centuries later, the descendants of these individuals, infused with Bio Particles, are chosen by Peebo and Bio Robo to become the Bioman team in order to protect the Earth from the Neo Gear Empire, an organization led by the mad scientist Doctor Man.